4FM6
HIV-1 protease mutant V32I complexed with reaction intermediate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | HIV-1 protease | polymer | 99 | 10754.7 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 (HIV-1) | PR, Retropepsin |
| 2 | C (C) | hexapeptide | polymer | 6 | 763.9 | 1 | Human immunodeficiency virus 1 (HIV-1) | ||
| 3 | D (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | E, F, G, H, I... (B, A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 5 | K (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | L, M, N (B, A, C) | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | engineered mutation |
| Ile 32 | Val 532 | engineered mutation |
| Ile 33 | Leu 533 | engineered mutation |
| Ile 63 | Leu 563 | engineered mutation |
| Ala 67 | Cys 567 | engineered mutation |
| Ala 95 | Cys 595 | engineered mutation |
| Ile 32 | Val 532 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22273.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 327.8 | |
| All* | Total formula weight | 22601.1 |
