4FAT

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Summary for 4FAT

Entry DOI	10.2210/pdb4fat/pdb
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, 2-({[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ... (7 entities in total)
Functional Keywords	transport protein, ion channel, chimera protein, membrane protein
Biological source	Rattus norvegicus (brown rat,rat,rats) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	1
Total formula weight	30390.70
Authors	Maclean, J.K.F.,Kazemier, B. (deposition date: 2012-05-22, release date: 2012-07-11, Last modification date: 2023-09-13)
Primary citation	Harms, J.E.,Benveniste, M.,Maclean, J.K.,Partin, K.M.,Jamieson, C. Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology, 64:45-52, 2013 Cited by PubMed: 22735771 DOI: 10.1016/j.neuropharm.2012.06.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation