4FAT
Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
Summary for 4FAT
Entry DOI | 10.2210/pdb4fat/pdb |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, 2-({[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ... (7 entities in total) |
Functional Keywords | transport protein, ion channel, chimera protein, membrane protein |
Biological source | Rattus norvegicus (brown rat,rat,rats) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 1 |
Total formula weight | 30390.70 |
Authors | Maclean, J.K.F.,Kazemier, B. (deposition date: 2012-05-22, release date: 2012-07-11, Last modification date: 2023-09-13) |
Primary citation | Harms, J.E.,Benveniste, M.,Maclean, J.K.,Partin, K.M.,Jamieson, C. Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology, 64:45-52, 2013 Cited by PubMed: 22735771DOI: 10.1016/j.neuropharm.2012.06.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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