Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLU A 301 |
| Chain | Residue |
| A | TYR61 |
| A | HOH422 |
| A | HOH426 |
| A | HOH430 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 496 A 302 |
| Chain | Residue |
| A | ILE92 |
| A | PRO105 |
| A | PRO105 |
| A | PHE106 |
| A | PHE106 |
| A | MET107 |
| A | SER108 |
| A | SER108 |
| A | SER217 |
| A | SER217 |
| A | LYS218 |
| A | LYS218 |
| A | GLY219 |
| A | GLY219 |
| A | LEU239 |
| A | LEU239 |
| A | SER242 |
| A | SER242 |
| A | HOH460 |
| A | HOH649 |
| A | HOH650 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 303 |
| Chain | Residue |
| A | HIS23 |
| A | GLU24 |
| A | ARG31 |
| A | HIS46 |
| A | LYS240 |
| A | HOH723 |
| A | HOH732 |
| A | HOH770 |
| A | HOH771 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 304 |
| Chain | Residue |
| A | GLU27 |
| A | GLY28 |
| A | ASN29 |
| A | GLU30 |
| A | ARG149 |
| A | LYS151 |
| A | HOH551 |
| A | HOH604 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 305 |
| Chain | Residue |
| A | ASP139 |
| A | SER140 |
| A | LYS144 |
| A | GLU145 |
| A | ARG148 |
| A | GOL306 |
| A | HOH503 |
| A | HOH543 |
| A | HOH685 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 306 |
| Chain | Residue |
| A | GLY62 |
| A | ALA63 |
| A | TRP71 |
| A | THR93 |
| A | VAL95 |
| A | ARG96 |
| A | GLY141 |
| A | GLU145 |
| A | SO4305 |
| A | HOH419 |
| A | HOH658 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 307 |
| Chain | Residue |
| A | ARG148 |
| A | TRP159 |
| A | ARG163 |
| A | HOH741 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 308 |
| Chain | Residue |
| A | SER108 |
| A | LEU109 |
| A | SER194 |
| A | THR195 |
| A | GLU198 |
| A | ASN214 |
| A | HOH471 |
| A | HOH605 |
| A | HOH774 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 309 |
| Chain | Residue |
| A | ASN214 |
| A | ASP216 |
| A | SER217 |
| A | ASP248 |
| A | HOH638 |
| A | HOH715 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LI A 310 |
| Chain | Residue |
| A | GLU97 |
| A | ILE100 |
| A | ASP101 |
| A | HOH427 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | ALA134-VAL154 | |
| A | ASP207-GLY227 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 31 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | PHE155-VAL181 | |
| A | GLU201-CYS206 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | INTRAMEM: Helical; Pore-forming |
| Chain | Residue | Details |
| A | ARG182-ASN197 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | GLU198-ILE200 | |
| Chain | Residue | Details |
| A | TYR61 | |
| A | ARG96 | |
| A | GLU193 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | PRO89 | |
| Chain | Residue | Details |
| A | THR91 | |
| A | SER142 | |
| A | THR143 | |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG64 | |
| A | ARG148 | |
| A | LYS240 | |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE121 | |
| Chain | Residue | Details |
| A | SER150 | |
| Chain | Residue | Details |
| A | SER184 | |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE200 | |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
