4FAT

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU A 301

Chain	Residue
A	TYR61
A	HOH422
A	HOH426
A	HOH430
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 496 A 302

Chain	Residue
A	ILE92
A	PRO105
A	PRO105
A	PHE106
A	PHE106
A	MET107
A	SER108
A	SER108
A	SER217
A	SER217
A	LYS218
A	LYS218
A	GLY219
A	GLY219
A	LEU239
A	LEU239
A	SER242
A	SER242
A	HOH460
A	HOH649
A	HOH650

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	HIS23
A	GLU24
A	ARG31
A	HIS46
A	LYS240
A	HOH723
A	HOH732
A	HOH770
A	HOH771

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	GLU27
A	GLY28
A	ASN29
A	GLU30
A	ARG149
A	LYS151
A	HOH551
A	HOH604

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	ASP139
A	SER140
A	LYS144
A	GLU145
A	ARG148
A	GOL306
A	HOH503
A	HOH543
A	HOH685

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 306

Chain	Residue
A	GLY62
A	ALA63
A	TRP71
A	THR93
A	VAL95
A	ARG96
A	GLY141
A	GLU145
A	SO4305
A	HOH419
A	HOH658

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 307

Chain	Residue
A	ARG148
A	TRP159
A	ARG163
A	HOH741

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 308

Chain	Residue
A	SER108
A	LEU109
A	SER194
A	THR195
A	GLU198
A	ASN214
A	HOH471
A	HOH605
A	HOH774

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 309

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	ASP248
A	HOH638
A	HOH715

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LI A 310

Chain	Residue
A	GLU97
A	ILE100
A	ASP101
A	HOH427

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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