4EB8
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
Summary for 4EB8
Entry DOI | 10.2210/pdb4eb8/pdb |
Related | 4EAR |
Descriptor | Purine nucleoside phosphorylase, PHOSPHATE ION, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, ... (5 entities in total) |
Functional Keywords | pnp, immucillin, purine nucleoside phosphorylase, nucleoside binding, purine base binding, purine-nucleoside phosphorylase activity, drug binding, transferase activity, transferring glycosyl groups, phosphate ion binding, intracellular, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton (By similarity): P00491 |
Total number of polymer chains | 3 |
Total formula weight | 109628.32 |
Authors | Ho, M.C.,Haapalainen, A.M.,Suarez, J.J.,Almo, S.C.,Schramm, V.L. (deposition date: 2012-03-23, release date: 2013-02-06, Last modification date: 2024-02-28) |
Primary citation | Suarez, J.,Haapalainen, A.M.,Cahill, S.M.,Ho, M.C.,Yan, F.,Almo, S.C.,Schramm, V.L. Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol., 20:212-222, 2013 Cited by PubMed: 23438750DOI: 10.1016/j.chembiol.2013.01.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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