4E73
Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor
Summary for 4E73
Entry DOI | 10.2210/pdb4e73/pdb |
Related | 1UKH |
Descriptor | Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, methyl 3-(4-{[(1R,2S,3S,5S,7s)-5-aminotricyclo[3.3.1.1~3,7~]dec-2-yl]carbamoyl}benzyl)-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-2-carboxylate, ... (4 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P45983 Cytoplasm (By similarity): Q9UQF2 |
Total number of polymer chains | 2 |
Total formula weight | 44468.45 |
Authors | Lukacs, C.M.,Janson, C.A. (deposition date: 2012-03-16, release date: 2013-05-29, Last modification date: 2023-09-13) |
Primary citation | Haynes, N.E.,Scott, N.R.,Chen, L.C.,Janson, C.A.,Li, J.K.,Lukacs, C.M.,Railkar, A.,Tozzo, E.,Whittard, T.,Brown, N.F.,Cheung, A.W. Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor. ACS Med Chem Lett, 3:764-768, 2012 Cited by PubMed: 24900545DOI: 10.1021/ml300175c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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