4DN4
Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a
Summary for 4DN4
Entry DOI | 10.2210/pdb4dn4/pdb |
Related | 4DN3 |
Descriptor | CNTO888 LIGHT CHAIN, CNTO888 HEAVY CHAIN, C-C motif chemokine 2, ... (6 entities in total) |
Functional Keywords | antibody chemokine, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted : P13500 |
Total number of polymer chains | 3 |
Total formula weight | 56742.44 |
Authors | Obmolova, G.,Teplyakov, A.,Malia, T.,Grygiel, T.,Sweet, R.,Snyder, L.,Gilliland, G. (deposition date: 2012-02-08, release date: 2012-10-03, Last modification date: 2018-01-24) |
Primary citation | Obmolova, G.,Teplyakov, A.,Malia, T.J.,Grygiel, T.L.,Sweet, R.,Snyder, L.A.,Gilliland, G.L. Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888. Mol.Immunol., 51:227-233, 2012 Cited by PubMed: 22487721DOI: 10.1016/j.molimm.2012.03.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report