4DKL

Crystal structure of the mu-opioid receptor bound to a morphinan antagonist

Summary for 4DKL

• Entry DOI: 10.2210/pdb4dkl/pdb
• Descriptor: Mu-type opioid receptor, lysozyme chimera, methyl 4-{[(5beta,6alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]amino}-4-oxobutanoate, SULFATE ION, ... (8 entities in total)
• Functional Keywords: g-protein coupled receptor, 7 transmembrane receptor, signaling protein-antagonist complex, signaling protein/antagonist
• Biological source: Mus musculus (mouse, bacteriophage T4); More
• Cellular location: Cell membrane ; Multi- pass membrane protein : P42866
• Total number of polymer chains: 1
• Total formula weight: 55761.67

Authors

Manglik, A.,Kruse, A.C.,Kobilka, T.S.,Thian, F.S.,Mathiesen, J.M.,Sunahara, R.K.,Pardo, L.,Weis, W.I.,Kobilka, B.K.,Granier, S. (deposition date: 2012-02-03, release date: 2012-03-21, Last modification date: 2023-09-13)

• Primary citation: Manglik, A.,Kruse, A.C.,Kobilka, T.S.,Thian, F.S.,Mathiesen, J.M.,Sunahara, R.K.,Pardo, L.,Weis, W.I.,Kobilka, B.K.,Granier, S.; Crystal structure of the {mu}-opioid receptor bound to a morphinan antagonist.; Nature, 485:321-326, 2012; PubMed: 22437502; DOI: 10.1038/nature10954

Experimental method

X-RAY DIFFRACTION (2.8 Å)