4CDG

Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody

Summary for 4CDG

• Entry DOI: 10.2210/pdb4cdg/pdb
• Descriptor: BLOOM SYNDROME PROTEIN, NANOBODY, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: hydrolase
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus : P54132
• Total number of polymer chains: 4
• Total formula weight: 186736.26

Authors

Newman, J.A.,Savitsky, P.,Allerston, C.K.,Pike, A.C.W.,Pardon, E.,Steyaert, J.,Arrowsmith, C.H.,von Delft, F.,Bountra, C.,Edwards, A.,Gileadi, O. (deposition date: 2013-10-31, release date: 2013-11-13, Last modification date: 2023-12-20)

• Primary citation: Newman, J.A.,Savitsky, P.,Allerston, C.K.,Bizard, A.H.,Ozer, O.,Sarlos, K.,Liu, Y.,Pardon, E.,Steyaert, J.,Hickson, I.D.,Gileadi, O.; Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes.; Nucleic Acids Res., 43:5221-, 2015; PubMed: 25901030; DOI: 10.1093/NAR/GKV373

Experimental method

X-RAY DIFFRACTION (2.794 Å)