4BQH
Crystal structure of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei in complex with inhibitor
Summary for 4BQH
Entry DOI | 10.2210/pdb4bqh/pdb |
Descriptor | UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE, SULFATE ION, (3S)-3-[2-(1,3-benzodioxol-5-yl)-2-oxidanylidene-ethyl]-4-bromanyl-5-methyl-3-oxidanyl-1H-indol-2-one, ... (4 entities in total) |
Functional Keywords | transferase, inhibitor |
Biological source | TRYPANOSOMA BRUCEI |
Total number of polymer chains | 1 |
Total formula weight | 61195.09 |
Authors | Fang, W.,Raimi, O.G.,vanAalten, D.M.F. (deposition date: 2013-05-30, release date: 2013-07-17, Last modification date: 2023-12-20) |
Primary citation | Urbaniak, M.D.,Collie, I.T.,Fang, W.,Aristotelous, T.,Eskilsson, S.,Raimi, O.G.,Harrison, J.,Hopkins Navratolova, I.,Frearson, J.A.,Van Aalten, D.M.F.,Ferguson, M.A.J. A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma Brucei. Acs Chem.Biol., 8:1981-, 2013 Cited by PubMed: 23834437DOI: 10.1021/CB400411X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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