4A06
Human PDK1 Kinase Domain in Complex with Allosteric Activator PS114 Bound to the PIF-Pocket
Summary for 4A06
Entry DOI | 10.2210/pdb4a06/pdb |
Related | 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2VKI 2XCH 2XCK 4A07 |
Descriptor | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, (3S)-4-(5-chloro-1H-benzimidazol-2-yl)-3-(4-chlorophenyl)butanoic acid, ... (6 entities in total) |
Functional Keywords | transferase, allosteric site |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: O15530 |
Total number of polymer chains | 1 |
Total formula weight | 36610.72 |
Authors | Schulze, J.O.,Lopez-Garcia, L.A.,Froehner, W.,Zhang, H.,Navratil, J.,Hindie, V.,Zeuzem, S.,Alzari, P.M.,Neimanis, S.,Engel, M.,Biondi, R.M. (deposition date: 2011-09-08, release date: 2011-12-07, Last modification date: 2023-12-20) |
Primary citation | Lopez-Garcia, L.A.,Schulze, J.O.,Frohner, W.,Zhang, H.,Suss, E.,Weber, N.,Navratil, J.,Amon, S.,Hindie, V.,Zeuzem, S.,Jorgensen, T.J.,Alzari, P.M.,Neimanis, S.,Engel, M.,Biondi, R.M. Allosteric Regulation of Protein Kinase Pkczeta by the N-Terminal C1 Domain and Small Compounds to the Pif-Pocket. Chem.Biol., 18:1463-, 2011 Cited by PubMed: 22118680DOI: 10.1016/J.CHEMBIOL.2011.08.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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