4A06
Human PDK1 Kinase Domain in Complex with Allosteric Activator PS114 Bound to the PIF-Pocket
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 | polymer | 311 | 35392.6 | 1 | UniProt (O15530) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | HPDK1 |
| 2 | B (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 3 | C (A) | (3S)-4-(5-chloro-1H-benzimidazol-2-yl)-3-(4-chlorophenyl)butanoic acid | non-polymer | 349.2 | 1 | Chemie (A06) | |||
| 4 | D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | E, F, G, H, I... (A) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 6 | M (A) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A: 50 - 359 (UniProt: O15530)
| PDB | External Database | Details |
|---|---|---|
| Gly 49 | - | expression tag |
| Gly 288 | Tyr 288 | engineered mutation |
| Ala 292 | Gln 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35392.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1218.1 | |
| All* | Total formula weight | 36610.7 |
