43NO

Crystal structure of a de novo-designed Binder targeting VEGFA

Summary for 43NO

• Entry DOI: 10.2210/pdb43no/pdb
• Descriptor: VEGFA_Binder-004, Vascular endothelial growth factor A, long form, GLYCEROL, ... (4 entities in total)
• Functional Keywords: vegfa, ppiflow, de novo protein, dingle digit nanomolar binder, minibinder
• Biological source: synthetic construct; More
• Total number of polymer chains: 8
• Total formula weight: 108949.38

Authors

Wang, S.,Yu, Q.L.,Tian, B.H.,Qin, X.Y.,Chen, M.C. (deposition date: 2026-07-09, release date: 2026-08-05)

• Primary citation: Yu, Q.L.,Guo, L.Y.,Qin, X.Y.,Huang, X.K.,Tian, B.H.,Wang, H.Z.,Liu, Y.,Wang, S.,Lang, Y.Z.,Shen, Z.H.Y.,Lin, J.,Chen, M.C.; High-Affinity Protein Binder Design via Flow Matching and In Silico Maturation; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)