3ZWS

Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor

Summary for 3ZWS

Entry DOI	10.2210/pdb3zws/pdb
Related	1D3G 1D3H 2B0M 2BXV 2WV8 3ZWT
Descriptor	DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
Functional Keywords	oxidoreductase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Mitochondrion inner membrane; Single-pass membrane protein: Q02127
Total number of polymer chains	1
Total formula weight	41155.86
Authors	Acklam, P.A.,Parsons, M.R. (deposition date: 2011-08-02, release date: 2012-06-27, Last modification date: 2024-05-08)
Primary citation	Bedingfield, P.T.P.,Cowen, D.,Acklam, P.A.,Cunningham, F.,Parsons, M.R.,Mcconkey, G.A.,Fishwick, C.W.G.,Johnson, A.P. Factors Influencing the Specificity of Inhibitor Binding to the Human and Malaria Parasite Dihydroorotate Dehydrogenases. J.Med.Chem., 55:5841-, 2012 Cited by PubMed: 22621375 DOI: 10.1021/JM300157N PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation