3ZTX

Aurora kinase selective inhibitors identified using a Taxol-induced checkpoint sensitivity screen.

Summary for 3ZTX

Entry DOI	10.2210/pdb3ztx/pdb
Related	2BFX 2BFY 2VGO 2VGP 2VRX
Descriptor	SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, 2-((4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL)AMINO)-5,11-DIMETHYL-5H-BENZO[E]PYRIMIDO [5,4-B][1,4]DIAZEPIN-6(11H)-ONE, ... (4 entities in total)
Functional Keywords	transferase-cell cycle complex, transferase, taxol-induced checkpoint inhibitor, transferase/cell cycle
Biological source	XENOPUS LAEVIS More
Cellular location	Nucleus: Q6DE08 Chromosome, centromere: O13024
Total number of polymer chains	4
Total formula weight	78084.26
Authors	Kwiatkowski, N.,Villa, F.,Musacchio, A.,Gray, N. (deposition date: 2011-07-12, release date: 2012-02-01)
Primary citation	Kwiatkowski, N.,Deng, X.,Wang, J.,Tan, L.,Villa, F.,Santaguida, S.,Huang, H.C.,Mitchison, T.,Musacchio, A.,Gray, N. Selective Aurora Kinase Inhibitors Identified Using a Taxol- Induced Checkpoint Sensitivity Screen. Acs Chem.Biol., 7:185-, 2012 Cited by PubMed: 21992004 DOI: 10.1021/CB200305U PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation