3ZTX

Aurora kinase selective inhibitors identified using a Taxol-induced checkpoint sensitivity screen.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	SERINE/THREONINE-PROTEIN KINASE 12-A	polymer	284	33537.9	2	UniProt (Q6DE08) Pfam (PF00069)	XENOPUS LAEVIS	AURORA B, AURORA KINASE B-A, AURORA/IPL1-RELATED KINASE 2, A XAIRK2, SERINE/THREONINE-PROTEIN KINASE AURORA-B-A, XAURORA-B
2	C, D (C, D)	INNER CENTROMERE PROTEIN A	polymer	44	5073.8	2	UniProt (O13024) Pfam (PF03941)	XENOPUS LAEVIS	XL-INCENP, XINC, XINCENP, MITOTIC PHOSPHOPROTEIN 130
3	E, F (A, B)	2-((4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL)AMINO)-5,11-DIMETHYL-5H-BENZO[E]PYRIMIDO [5,4-B][1,4]DIAZEPIN-6(11H)-ONE	non-polymer		430.5	2	Chemie (ZTX)
4	G, H, I, J (A, B, C, D)	water	water		18.0	285	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	77223.3
Non-Polymers*	Number of molecules	2
	Total formula weight	861.0
All*	Total formula weight	78084.3

*Water molecules are not included.