3ZKS
BACE2 XAPERONE COMPLEX WITH INHIBITOR
Summary for 3ZKS
Entry DOI | 10.2210/pdb3zks/pdb |
Related | 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ |
Descriptor | BETA-SECRETASE 2, XA4813, 5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-2-amino-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-4-yl)-phenyl]-amide, ... (4 entities in total) |
Functional Keywords | hydrolase-immune system complex, inhibitor, nanobody, hydrolase/immune system |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Membrane; Single-pass type I membrane protein: Q9Y5Z0 |
Total number of polymer chains | 2 |
Total formula weight | 55693.31 |
Authors | Banner, D.W.,Kuglstatter, A.,Benz, J.,Stihle, M.,Ruf, A. (deposition date: 2013-01-24, release date: 2013-05-29, Last modification date: 2023-12-20) |
Primary citation | Banner, D.W.,Gsell, B.,Benz, J.,Bertschinger, J.,Burger, D.,Brack, S.,Cuppuleri, S.,Debulpaep, M.,Gast, A.,Grabulovski, D.,Hennig, M.,Hilpert, H.,Huber, W.,Kuglstatter, A.,Kusznir, E.,Laeremans, T.,Matile, H.,Miscenic, C.,Rufer, A.,Schlatter, D.,Steyeart, J.,Stihle, M.,Thoma, R.,Weber, M.,Ruf, A. Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones Acta Crystallogr.,Sect.D, 69:1124-, 2013 Cited by PubMed: 23695257DOI: 10.1107/S0907444913006574 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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