3ZCQ

Rabbit muscle glycogen phosphorylase b in complex with N-(4- trifluoromethyl-benzoyl)-N-beta-D-glucopyranosyl urea determined at 2. 15 A resolution

3ZCQ の概要

• エントリーDOI: 10.2210/pdb3zcq/pdb
• 関連するPDBエントリー: 3ZCP 3ZCR 3ZCS 3ZCT 3ZCU 3ZCV
• 分子名称: GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, PYRIDOXAL-5'-PHOSPHATE, N-{[4-(trifluoromethyl)benzoyl]carbamoyl}-beta-D-glucopyranosylamine, ... (5 entities in total)
• 機能のキーワード: transferase, inhibitor, hypoglycaemic agents, structure-based ligand design
• 由来する生物種: ORYCTOLAGUS CUNICULUS (RABBIT)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98158.81

構造登録者

Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L. (登録日: 2012-11-21, 公開日: 2013-12-11, 最終更新日: 2023-12-20)

• 主引用文献: Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L.; Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents; To be Published,

実験手法

X-RAY DIFFRACTION (2.15 Å)