3ZCQ
Rabbit muscle glycogen phosphorylase b in complex with N-(4- trifluoromethyl-benzoyl)-N-beta-D-glucopyranosyl urea determined at 2. 15 A resolution
Summary for 3ZCQ
Entry DOI | 10.2210/pdb3zcq/pdb |
Related | 3ZCP 3ZCR 3ZCS 3ZCT 3ZCU 3ZCV |
Descriptor | GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, PYRIDOXAL-5'-PHOSPHATE, N-{[4-(trifluoromethyl)benzoyl]carbamoyl}-beta-D-glucopyranosylamine, ... (5 entities in total) |
Functional Keywords | transferase, inhibitor, hypoglycaemic agents, structure-based ligand design |
Biological source | ORYCTOLAGUS CUNICULUS (RABBIT) |
Total number of polymer chains | 1 |
Total formula weight | 98158.81 |
Authors | Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L. (deposition date: 2012-11-21, release date: 2013-12-11, Last modification date: 2023-12-20) |
Primary citation | Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L. Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents To be Published, |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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