3ZC5

X-ray Structure of c-Met kinase in complex with inhibitor (S)-6-(1-(6- (1-methyl-1H-pyrazol-4-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)ethyl) quinoline.

Summary for 3ZC5

• Entry DOI: 10.2210/pdb3zc5/pdb
• Related: 3ZBX
• Descriptor: HEPATOCYTE GROWTH FACTOR RECEPTOR, 6-{(1S)-1-[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinoline (3 entities in total)
• Functional Keywords: transferase, kinase, inhibitor
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 35234.81

Authors

McTigue, M.,Grodsky, N.,Ryan, K. (deposition date: 2012-11-15, release date: 2013-11-27, Last modification date: 2023-12-20)

• Primary citation: Cui, J.J.,Shen, H.,Tran-Dube, M.,Nambu, M.,Mctigue, M.,Grodsky, N.,Ryan, K.,Yamazaki, S.,Aguirre, S.,Parker, M.,Li, Q.,Zou, H.,Christensen, J.; Lessons from (S)-6-(1-(6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2, 4]Triazolo[4,3-B]Pyridazin-3-Yl)Ethyl)Quinoline (Pf-04254644), an Inhibitor of Receptor Tyrosine Kinase C-met with High Protein Kinase Selectivity But Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats.; J.Med.Chem., 56:6651-, 2013; PubMed: 23944843; DOI: 10.1021/JM400926X

Experimental method

X-RAY DIFFRACTION (2.2 Å)