3WIH
Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A.
Summary for 3WIH
Entry DOI | 10.2210/pdb3wih/pdb |
Related | 3WII |
Descriptor | Roundabout homolog 1, anti-human ROBO1 antibody B2212A Fab light chain, anti-human ROBO1 antibody B2212A Fab heavy chain, ... (5 entities in total) |
Functional Keywords | fibronectin type-iii domain, hepatocellular carcinoma antigen, angiogenesis, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Single-pass type I membrane protein : Q9Y6N7 |
Total number of polymer chains | 6 |
Total formula weight | 115504.10 |
Authors | Nakayama, T.,Mizohata, E.,Yamashita, T.,Nagatoishi, M.,Iwanari, H.,Mochizuki, Y.,Kado, Y.,Yokota, Y.,Sato, R.,Tsumoto, K.,Fujitani, H.,Kodama, T.,Hamakubo, T.,Inoue, T. (deposition date: 2013-09-12, release date: 2015-01-21, Last modification date: 2023-11-08) |
Primary citation | Nakayama, T.,Mizohata, E.,Yamashita, T.,Nagatoishi, S.,Nakakido, M.,Iwanari, H.,Mochizuki, Y.,Kado, Y.,Yokota, Y.,Satoh, R.,Tsumoto, K.,Fujitani, H.,Kodama, T.,Hamakubo, T.,Inoue, T. Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses Protein Sci., 24:328-340, 2015 Cited by PubMed: 25492858DOI: 10.1002/pro.2619 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.701 Å) |
Structure validation
Download full validation report