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3WIH

Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A.

Summary for 3WIH
Entry DOI10.2210/pdb3wih/pdb
Related3WII
DescriptorRoundabout homolog 1, anti-human ROBO1 antibody B2212A Fab light chain, anti-human ROBO1 antibody B2212A Fab heavy chain, ... (5 entities in total)
Functional Keywordsfibronectin type-iii domain, hepatocellular carcinoma antigen, angiogenesis, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane ; Single-pass type I membrane protein : Q9Y6N7
Total number of polymer chains6
Total formula weight115504.10
Authors
Nakayama, T.,Mizohata, E.,Yamashita, T.,Nagatoishi, M.,Iwanari, H.,Mochizuki, Y.,Kado, Y.,Yokota, Y.,Sato, R.,Tsumoto, K.,Fujitani, H.,Kodama, T.,Hamakubo, T.,Inoue, T. (deposition date: 2013-09-12, release date: 2015-01-21, Last modification date: 2023-11-08)
Primary citationNakayama, T.,Mizohata, E.,Yamashita, T.,Nagatoishi, S.,Nakakido, M.,Iwanari, H.,Mochizuki, Y.,Kado, Y.,Yokota, Y.,Satoh, R.,Tsumoto, K.,Fujitani, H.,Kodama, T.,Hamakubo, T.,Inoue, T.
Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses
Protein Sci., 24:328-340, 2015
Cited by
PubMed: 25492858
DOI: 10.1002/pro.2619
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.701 Å)
Structure validation

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