3WEJ

Crystal structure of the human squalene synthase F288A mutant in complex with presqualene pyrophosphate

Summary for 3WEJ

Entry DOI	10.2210/pdb3wej/pdb
Related	3VJ8 3VJ9 3VJA 3VJB 3VJC 3VJD 3WEF 3WEG 3WEH 3WEI 3WEK
Descriptor	Squalene synthase, MAGNESIUM ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate, ... (4 entities in total)
Functional Keywords	farnesyl-diphosphate farnesyltransferase, head-to-head synthases, cholesterol biosynthesis, oxidoreductase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40008.16
Authors	Liu, C.I.,Jeng, W.Y.,Wang, A.H.J. (deposition date: 2013-07-07, release date: 2014-02-12, Last modification date: 2023-11-08)
Primary citation	Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Shih, M.F.,Ko, T.P.,Wang, A.H.J. Structural insights into the catalytic mechanism of human squalene synthase. Acta Crystallogr.,Sect.D, 70:231-241, 2014 Cited by PubMed: 24531458 DOI: 10.1107/S1399004713026230 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation