Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3W2R

EGFR Kinase domain T790M/L858R mutant with compound 4

Summary for 3W2R
Entry DOI10.2210/pdb3w2r/pdb
Related3POZ 3W2O 3W2P 3W2Q 3W2S
DescriptorEpidermal growth factor receptor, 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5H-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsanti-oncogene, cell cycle, disease mutation, kinase domain, receptor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight38648.10
Authors
Sogabe, S.,Kawakita, Y.,Igaki, S. (deposition date: 2012-12-03, release date: 2013-01-16, Last modification date: 2023-11-08)
Primary citationSogabe, S.,Kawakita, Y.,Igaki, S.,Iwata, H.,Miki, H.,Cary, D.R.,Takagi, T.,Takagi, S.,Ohta, Y.,Ishikawa, T.
Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.
Acs Med.Chem.Lett., 4:201-205, 2013
Cited by
PubMed: 24900643
DOI: 10.1021/ml300327z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.05 Å)
Structure validation

217705

건을2024-03-27부터공개중

PDB statisticsPDBj update infoContact PDBjnumon