3W2R
EGFR Kinase domain T790M/L858R mutant with compound 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 331 | 38021.0 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5H-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea | non-polymer | 565.1 | 1 | Chemie (W2R) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A: 698 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| His 692 | - | expression tag |
| His 693 | - | expression tag |
| His 694 | - | expression tag |
| His 695 | - | expression tag |
| His 696 | - | expression tag |
| His 697 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 858 | Leu 858 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38021.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 627.1 | |
| All* | Total formula weight | 38648.1 |
