3W2Q

EGFR kinase domain T790M/L858R mutant with HKI-272

Summary for 3W2Q

Entry DOI	10.2210/pdb3w2q/pdb
Related	2JIV 3POZ 3W2O 3W2P 3W2R 3W2S
Descriptor	Epidermal growth factor receptor, N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	anti-oncogene, cell cycle, disease mutation, kinase domain, receptor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38775.26
Authors	Sogabe, S.,Kawakita, Y.,Igaki, S. (deposition date: 2012-12-03, release date: 2013-01-16, Last modification date: 2023-11-08)
Primary citation	Sogabe, S.,Kawakita, Y.,Igaki, S.,Iwata, H.,Miki, H.,Cary, D.R.,Takagi, T.,Takagi, S.,Ohta, Y.,Ishikawa, T. Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors. Acs Med.Chem.Lett., 4:201-205, 2013 Cited by PubMed: 24900643 DOI: 10.1021/ml300327z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation