3VT4

Crystal structures of rat VDR-LBD with R270L mutation

Summary for 3VT4

Related2ZLC 3VT3 3VT5 3VT6 3VT7 3VT8 3VT9
DescriptorVitamin D3 receptor, COACTIVATOR PEPTIDE DRIP, (1R,2Z,3R,5E,7E)-17-{(1S)-1-[(2-ethyl-2-hydroxybutyl)sulfanyl]ethyl}-2-(2-hydroxyethylidene)-9,10-secoestra-5,7,16-triene-1,3-diol, ... (4 entities in total)
Functional Keywordstranscription, hormone receptor
Biological sourceRattus norvegicus (rats)
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Cellular locationNucleus P13053
Total number of polymer chains2
Total molecular weight32598.61
Authors
Nakabayashi, M.,Shimizu, M.,Ikura, T.,Ito, N. (deposition date: 2012-05-19, release date: 2013-05-22, Last modification date: 2014-02-12)
Primary citation
Nakabayashi, M.,Tsukahara, Y.,Iwasaki-Miyamoto, Y.,Mihori-Shimazaki, M.,Yamada, S.,Inaba, S.,Oda, M.,Shimizu, M.,Makishima, M.,Tokiwa, H.,Ikura, T.,Ito, N.
Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands.
J.Med.Chem., 56:6745-6760, 2013
PubMed: 23944708 (PDB entries with the same primary citation)
DOI: 10.1021/jm400537h
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2591202.2%7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 3vt4
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Molmil generated image of 3vt4
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More Biological unit images

Molmil generated image of 3vt4
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Molmil generated image of 3vt4
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Molmil generated image of 3vt4
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3vt4.pdb2.gz [42.87 KB])
Coordinate files for Biological unit (3vt4.pdb1.gz [44.81 KB])
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