3VRR

Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant) in complex with phospho-EGFR peptide

Summary for 3VRR

Entry DOI	10.2210/pdb3vrr/pdb
Related	3VRN 3VRO 3VRP 3VRQ
Descriptor	Signal transduction protein CBL-C, Epidermal growth factor receptor, CALCIUM ION, ... (4 entities in total)
Functional Keywords	ptb domain, tkb (tyrosine kinase binding) domain, four-helix bundle (4h), calcium-binding ef hand, divergent sh2 domain, regulator of egfr mediated signal transduction, ubiquitously expressed, protein binding-transferase complex, protein binding/transferase
Biological source	Homo sapiens (human) More
Cellular location	Nucleus (Potential): Q9ULV8 Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	2
Total formula weight	38372.75
Authors	Takeshita, K.,Tezuka, T.,Isozaki, Y.,Yamashita, E.,Suzuki, M.,Yamanashi, Y.,Yamamoto, T.,Nakagawa, A. (deposition date: 2012-04-13, release date: 2013-03-06)
Primary citation	Takeshita, K.,Tezuka, T.,Isozaki, Y.,Yamashita, E.,Suzuki, M.,Kim, M.,Yamanashi, Y.,Yamamoto, T.,Nakagawa, A. Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. J.Biochem., 152:487-495, 2012 Cited by PubMed: 22888118 DOI: 10.1093/jb/mvs085 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation