3VRR
Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant) in complex with phospho-EGFR peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Signal transduction protein CBL-C | polymer | 331 | 36707.1 | 1 | UniProt (Q9ULV8) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) | Homo sapiens (human) | RING finger protein 57, SH3-binding protein CBL-3, SH3-binding protein CBL-C |
| 2 | B (C) | Epidermal growth factor receptor | polymer | 13 | 1625.6 | 1 | UniProt (P00533) | Homo sapiens | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A: 1 - 323 (UniProt: Q9ULV8)
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| Leu 265 | Pro 265 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38332.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 40.1 | |
| All* | Total formula weight | 38372.8 |
