3V6M

Inhibition of caspase-6 activity by single mutation outside the active site

Summary for 3V6M

Entry DOI	10.2210/pdb3v6m/pdb
Related	3NR2 3OD5 3V6L
Descriptor	Caspase-6 (2 entities in total)
Functional Keywords	caspase domain, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P55212
Total number of polymer chains	8
Total formula weight	257822.92
Authors	Cao, Q.,Wang, X.J.,Liu, D.F.,Li, L.F.,Su, X.D. (deposition date: 2011-12-20, release date: 2012-03-28, Last modification date: 2023-11-08)
Primary citation	Cao, Q.,Wang, X.J.,Liu, C.W.,Liu, D.F.,Li, L.F.,Gao, Y.Q.,Su, X.D. Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays J.Biol.Chem., 287:15371-15379, 2012 Cited by PubMed: 22433863 DOI: 10.1074/jbc.M112.351213 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.692 Å)

Structure validation