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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3V6M

Inhibition of caspase-6 activity by single mutation outside the active site

Functional Information from GO Data
ChainGOidnamespacecontents
A0002218biological_processactivation of innate immune response
A0004175molecular_functionendopeptidase activity
A0004197molecular_functioncysteine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0008233molecular_functionpeptidase activity
A0008234molecular_functioncysteine-type peptidase activity
A0016540biological_processprotein autoprocessing
A0016787molecular_functionhydrolase activity
A0030855biological_processepithelial cell differentiation
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043067biological_processregulation of programmed cell death
A0043525biological_processpositive regulation of neuron apoptotic process
A0051604biological_processprotein maturation
A0060545biological_processpositive regulation of necroptotic process
A0070269biological_processpyroptotic inflammatory response
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
A0072734biological_processcellular response to staurosporine
A0097284biological_processhepatocyte apoptotic process
B0002218biological_processactivation of innate immune response
B0004175molecular_functionendopeptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0008233molecular_functionpeptidase activity
B0008234molecular_functioncysteine-type peptidase activity
B0016540biological_processprotein autoprocessing
B0016787molecular_functionhydrolase activity
B0030855biological_processepithelial cell differentiation
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0043067biological_processregulation of programmed cell death
B0043525biological_processpositive regulation of neuron apoptotic process
B0051604biological_processprotein maturation
B0060545biological_processpositive regulation of necroptotic process
B0070269biological_processpyroptotic inflammatory response
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0072734biological_processcellular response to staurosporine
B0097284biological_processhepatocyte apoptotic process
C0002218biological_processactivation of innate immune response
C0004175molecular_functionendopeptidase activity
C0004197molecular_functioncysteine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006508biological_processproteolysis
C0006915biological_processapoptotic process
C0008233molecular_functionpeptidase activity
C0008234molecular_functioncysteine-type peptidase activity
C0016540biological_processprotein autoprocessing
C0016787molecular_functionhydrolase activity
C0030855biological_processepithelial cell differentiation
C0042802molecular_functionidentical protein binding
C0043065biological_processpositive regulation of apoptotic process
C0043067biological_processregulation of programmed cell death
C0043525biological_processpositive regulation of neuron apoptotic process
C0051604biological_processprotein maturation
C0060545biological_processpositive regulation of necroptotic process
C0070269biological_processpyroptotic inflammatory response
C0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
C0072734biological_processcellular response to staurosporine
C0097284biological_processhepatocyte apoptotic process
D0002218biological_processactivation of innate immune response
D0004175molecular_functionendopeptidase activity
D0004197molecular_functioncysteine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006508biological_processproteolysis
D0006915biological_processapoptotic process
D0008233molecular_functionpeptidase activity
D0008234molecular_functioncysteine-type peptidase activity
D0016540biological_processprotein autoprocessing
D0016787molecular_functionhydrolase activity
D0030855biological_processepithelial cell differentiation
D0042802molecular_functionidentical protein binding
D0043065biological_processpositive regulation of apoptotic process
D0043067biological_processregulation of programmed cell death
D0043525biological_processpositive regulation of neuron apoptotic process
D0051604biological_processprotein maturation
D0060545biological_processpositive regulation of necroptotic process
D0070269biological_processpyroptotic inflammatory response
D0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
D0072734biological_processcellular response to staurosporine
D0097284biological_processhepatocyte apoptotic process
F0002218biological_processactivation of innate immune response
F0004175molecular_functionendopeptidase activity
F0004197molecular_functioncysteine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006508biological_processproteolysis
F0006915biological_processapoptotic process
F0008233molecular_functionpeptidase activity
F0008234molecular_functioncysteine-type peptidase activity
F0016540biological_processprotein autoprocessing
F0016787molecular_functionhydrolase activity
F0030855biological_processepithelial cell differentiation
F0042802molecular_functionidentical protein binding
F0043065biological_processpositive regulation of apoptotic process
F0043067biological_processregulation of programmed cell death
F0043525biological_processpositive regulation of neuron apoptotic process
F0051604biological_processprotein maturation
F0060545biological_processpositive regulation of necroptotic process
F0070269biological_processpyroptotic inflammatory response
F0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
F0072734biological_processcellular response to staurosporine
F0097284biological_processhepatocyte apoptotic process
G0002218biological_processactivation of innate immune response
G0004175molecular_functionendopeptidase activity
G0004197molecular_functioncysteine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006508biological_processproteolysis
G0006915biological_processapoptotic process
G0008233molecular_functionpeptidase activity
G0008234molecular_functioncysteine-type peptidase activity
G0016540biological_processprotein autoprocessing
G0016787molecular_functionhydrolase activity
G0030855biological_processepithelial cell differentiation
G0042802molecular_functionidentical protein binding
G0043065biological_processpositive regulation of apoptotic process
G0043067biological_processregulation of programmed cell death
G0043525biological_processpositive regulation of neuron apoptotic process
G0051604biological_processprotein maturation
G0060545biological_processpositive regulation of necroptotic process
G0070269biological_processpyroptotic inflammatory response
G0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
G0072734biological_processcellular response to staurosporine
G0097284biological_processhepatocyte apoptotic process
I0002218biological_processactivation of innate immune response
I0004175molecular_functionendopeptidase activity
I0004197molecular_functioncysteine-type endopeptidase activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006508biological_processproteolysis
I0006915biological_processapoptotic process
I0008233molecular_functionpeptidase activity
I0008234molecular_functioncysteine-type peptidase activity
I0016540biological_processprotein autoprocessing
I0016787molecular_functionhydrolase activity
I0030855biological_processepithelial cell differentiation
I0042802molecular_functionidentical protein binding
I0043065biological_processpositive regulation of apoptotic process
I0043067biological_processregulation of programmed cell death
I0043525biological_processpositive regulation of neuron apoptotic process
I0051604biological_processprotein maturation
I0060545biological_processpositive regulation of necroptotic process
I0070269biological_processpyroptotic inflammatory response
I0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
I0072734biological_processcellular response to staurosporine
I0097284biological_processhepatocyte apoptotic process
J0002218biological_processactivation of innate immune response
J0004175molecular_functionendopeptidase activity
J0004197molecular_functioncysteine-type endopeptidase activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006508biological_processproteolysis
J0006915biological_processapoptotic process
J0008233molecular_functionpeptidase activity
J0008234molecular_functioncysteine-type peptidase activity
J0016540biological_processprotein autoprocessing
J0016787molecular_functionhydrolase activity
J0030855biological_processepithelial cell differentiation
J0042802molecular_functionidentical protein binding
J0043065biological_processpositive regulation of apoptotic process
J0043067biological_processregulation of programmed cell death
J0043525biological_processpositive regulation of neuron apoptotic process
J0051604biological_processprotein maturation
J0060545biological_processpositive regulation of necroptotic process
J0070269biological_processpyroptotic inflammatory response
J0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
J0072734biological_processcellular response to staurosporine
J0097284biological_processhepatocyte apoptotic process
Functional Information from PROSITE/UniProt
site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HadadCfvCvFLSHG
ChainResidueDetails
AHIS108-GLY122
site_idPS01122
Number of Residues12
DetailsCASPASE_CYS Caspase family cysteine active site. KPKIFIIQACRG
ChainResidueDetails
ALYS154-GLY165
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsRegion: {"description":"Tri-arginine exosite","evidences":[{"source":"PubMed","id":"30420425","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues136
DetailsRegion: {"description":"130's region","evidences":[{"source":"PubMed","id":"28154009","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsActive site: {"evidences":[{"source":"PubMed","id":"30420425","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsActive site: {"evidences":[{"source":"PubMed","id":"16123779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19133298","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19694615","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20890311","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28864531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30420425","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O08738","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine; by NUAK1 and AMPK","evidences":[{"source":"PubMed","id":"15273717","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22483120","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32029622","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"27911442","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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