3V6M

Inhibition of caspase-6 activity by single mutation outside the active site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, F...)	Caspase-6	polymer	279	32227.9	8	UniProt (P55212) Pfam (PF00656)	Homo sapiens (human)	CASP-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11
2	I, J, K, L, M... (A, B, C, D, F...)	water	water		18.0	65	Chemie (HOH)

Sequence modifications

A, B, C, D, F, G, I, J: 24 - 293 (UniProt: P55212)

PDB	External Database	Details
Met 23	-	expression tag
Glu 257	Ser 257	SEE REMARK 999
Leu 294	-	expression tag
Glu 295	-	expression tag
His 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag
His 299	-	expression tag
His 300	-	expression tag
His 301	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	257822.9
All*	Total formula weight	257822.9

*Water molecules are not included.