3V6B

VEGFR-2/VEGF-E complex structure

Summary for 3V6B

• Entry DOI: 10.2210/pdb3v6b/pdb
• Related: 2GNN 2X1W 2X1X 3V2A
• Descriptor: VEGF-E, Vascular endothelial growth factor receptor 2 (2 entities in total)
• Functional Keywords: ig-homology domain, vegfr-2, growth factor receptor, vegf ligand, angiogenesis, membrane, vegf-e, orf virus, hormone-signaling protein complex, hormone/signaling protein
• Biological source: Orf virus (ORFV); More
• Cellular location: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• Total number of polymer chains: 2
• Total formula weight: 63198.73

Authors

Brozzo, M.S.,Leppanen, V.-M.,Winkler, F.K.,Kisko, K.,Ballmer-Hofer, K. (deposition date: 2011-12-19, release date: 2012-01-18, Last modification date: 2024-04-03)

• Primary citation: Brozzo, M.S.,Bjelic, S.,Kisko, K.,Schleier, T.,Leppanen, V.M.,Alitalo, K.,Winkler, F.K.,Ballmer-Hofer, K.; Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.; Blood, 119:1781-1788, 2012; PubMed: 22207738; DOI: 10.1182/blood-2011-11-390922

Experimental method

X-RAY DIFFRACTION (3.205 Å)