3V0N

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-GalNAc derived inhibitor (3GW and 4GW)

3V0N の概要

• エントリーDOI: 10.2210/pdb3v0n/pdb
• 関連するPDBエントリー: 3IOH 3IOI 3IOJ
• 分子名称: Histo-blood group ABO system transferase, MANGANESE (II) ION, 5-(5-formylthiophen-2-yl)uridine 5'-(trihydrogen diphosphate), ... (7 entities in total)
• 機能のキーワード: gta, abo, cisab mutant, rossmann fold, "closed" conformation, glycosyltransferase, glycoprotein, blood group antigen, udp-galnac, metal-binding, manganese, glycosylation, transmembrane, golgi apparatus, secreted, signal-anchor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71636.35

構造登録者

Palcic, M.M.,Jorgensen, R. (登録日: 2011-12-08, 公開日: 2013-01-23, 最終更新日: 2023-09-13)

• 主引用文献: Jrgensen, R.,Pesnot, T.,Lee, H.J.,Palcic, M.M.,Wagner, G.K.; Base-modified donor analogues reveal novel dynamic features of a glycosyltransferase.; J.Biol.Chem., 288:26201-26208, 2013; PubMed: 23836908; DOI: 10.1074/jbc.M113.465963

実験手法

X-RAY DIFFRACTION (1.75 Å)