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3V0M

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (5GW) and H-antigen acceptor

Summary for 3V0M
Entry DOI10.2210/pdb3v0m/pdb
Related3IOH 3IOI 3IOJ 3v0l 3v0n 3v0o 3v0p 3v0q
DescriptorHisto-blood group ABO system transferase, MANGANESE (II) ION, 5-phenyluridine 5'-(trihydrogen diphosphate), ... (6 entities in total)
Functional Keywordsgta, abo, cisab mutant, aa(gly)b, rossmann fold, "closed" conformation, glycosyltransferase, glycoprotein, blood group antigen, udp-galnac, metal-binding, manganese, glycosylation, transmembrane, golgi apparatus, secreted, signal-anchor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
Total number of polymer chains2
Total formula weight71351.49
Authors
Palcic, M.M.,Jorgensen, R. (deposition date: 2011-12-08, release date: 2013-01-23, Last modification date: 2023-09-13)
Primary citationJrgensen, R.,Pesnot, T.,Lee, H.J.,Palcic, M.M.,Wagner, G.K.
Base-modified Donor Analogues Reveal Novel Dynamic Features of a Glycosyltransferase.
J.Biol.Chem., 288:26201-26208, 2013
Cited by
PubMed: 23836908
DOI: 10.1074/jbc.M113.465963
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.68 Å)
Structure validation

217705

数据于2024-03-27公开中

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