3UZS
Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex
Summary for 3UZS
Entry DOI | 10.2210/pdb3uzs/pdb |
Related | 1OMW 3UZT |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total) |
Functional Keywords | protein-rna complex, protein kinase fold, rgs homology domain, pleckstrin homology domain, beta propeller, g protein-coupled receptor phosphorylation, rna aptamer, carboxymethylation, geranylgeranylation, transferase-rna complex, transferase/rna |
Biological source | Bos taurus (bovine) More |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212 |
Total number of polymer chains | 4 |
Total formula weight | 134677.33 |
Authors | Tesmer, J.J.G.,Tesmer, V.M. (deposition date: 2011-12-07, release date: 2012-07-11, Last modification date: 2023-09-13) |
Primary citation | Tesmer, V.M.,Lennarz, S.,Mayer, G.,Tesmer, J.J. Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer. Structure, 20:1300-1309, 2012 Cited by PubMed: 22727813DOI: 10.1016/j.str.2012.05.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.52 Å) |
Structure validation
Download full validation report