3UWL

Crystal structure of Enteroccocus faecalis thymidylate synthase (EfTS) in complex with 5-formyl tetrahydrofolate

Summary for 3UWL

• Entry DOI: 10.2210/pdb3uwl/pdb
• Descriptor: Thymidylate synthase, SULFATE ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (6 entities in total)
• Functional Keywords: methyltransferase, transferase
• Biological source: Enterococcus faecalis; More
• Total number of polymer chains: 4
• Total formula weight: 147715.94

Authors

Pozzi, C.,Catalano, A.,Cortesi, D.,Luciani, R.,Ferrari, S.,Fritz, T.,Costi, M.P.,Mangani, S. (deposition date: 2011-12-02, release date: 2012-08-29, Last modification date: 2023-09-13)

• Primary citation: Pozzi, C.,Ferrari, S.,Cortesi, D.,Luciani, R.,Stroud, R.M.,Catalano, A.,Costi, M.P.,Mangani, S.; The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.; Acta Crystallogr.,Sect.D, 68:1232-1241, 2012; PubMed: 22948925; DOI: 10.1107/S0907444912026236

Experimental method

X-RAY DIFFRACTION (2.07 Å)