3UVQ

Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative

3UVQ の概要

• エントリーDOI: 10.2210/pdb3uvq/pdb
• 関連するPDBエントリー: 3QUD 3QUE 3UVP 3UVR 3UVS
• 分子名称: Mitogen-activated protein kinase 14, N-{5-[(7-{[(2R)-2,3-dihydroxypropyl]oxy}-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulen-2-yl)amino]-2-fluorophenyl}benzamide, octyl beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: selective p38 inhibitor, sar, dibenzosuberone derivative, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42087.98

構造登録者

Mayer-Wrangowski, S.C.,Richters, A.,Gruetter, C.,Rauh, D. (登録日: 2011-11-30, 公開日: 2012-12-05, 最終更新日: 2023-11-08)

• 主引用文献: Fischer, S.,Wentsch, H.K.,Mayer-Wrangowski, S.C.,Zimmermann, M.,Bauer, S.M.,Storch, K.,Niess, R.,Koeberle, S.C.,Grutter, C.,Boeckler, F.M.,Rauh, D.,Laufer, S.A.; Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.; J.Med.Chem., 56:241-253, 2013; PubMed: 23270382; DOI: 10.1021/jm301539x

実験手法

X-RAY DIFFRACTION (2.2 Å)