3UVP
Human p38 MAP Kinase in Complex with a Benzamide Substituted Benzosuberone
Summary for 3UVP
Entry DOI | 10.2210/pdb3uvp/pdb |
Related | 3QUD 3QUE 3UVQ 3UVR 3UVS |
Descriptor | Mitogen-activated protein kinase 14, N-{2-fluoro-5-[(5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino]phenyl}benzamide, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | protein kinase, selective p38 inhibitor, sar, benzosuberon derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42242.23 |
Authors | Mayer-Wrangowski, S.C.,Richters, A.,Gruetter, C.,Rauh, D. (deposition date: 2011-11-30, release date: 2012-11-07, Last modification date: 2023-11-08) |
Primary citation | Martz, K.E.,Dorn, A.,Baur, B.,Schattel, V.,Goettert, M.I.,Mayer-Wrangowski, S.C.,Rauh, D.,Laufer, S.A. Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38 alpha Inhibitors. J.Med.Chem., 55:7862-7874, 2012 Cited by PubMed: 22897496DOI: 10.1021/jm300951u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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