3UVP

Human p38 MAP Kinase in Complex with a Benzamide Substituted Benzosuberone

3UVP の概要

• エントリーDOI: 10.2210/pdb3uvp/pdb
• 関連するPDBエントリー: 3QUD 3QUE 3UVQ 3UVR 3UVS
• 分子名称: Mitogen-activated protein kinase 14, N-{2-fluoro-5-[(5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino]phenyl}benzamide, octyl beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: protein kinase, selective p38 inhibitor, sar, benzosuberon derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42242.23

構造登録者

Mayer-Wrangowski, S.C.,Richters, A.,Gruetter, C.,Rauh, D. (登録日: 2011-11-30, 公開日: 2012-11-07, 最終更新日: 2023-11-08)

• 主引用文献: Martz, K.E.,Dorn, A.,Baur, B.,Schattel, V.,Goettert, M.I.,Mayer-Wrangowski, S.C.,Rauh, D.,Laufer, S.A.; Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38 alpha Inhibitors.; J.Med.Chem., 55:7862-7874, 2012; PubMed: 22897496; DOI: 10.1021/jm300951u

実験手法

X-RAY DIFFRACTION (2.4 Å)