3UH4

TANKYRASE-1 complexed with NVP-XAV939

Summary for 3UH4

• Entry DOI: 10.2210/pdb3uh4/pdb
• Related: 3UH2
• Descriptor: Tankyrase-1, ZINC ION, 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, ... (6 entities in total)
• Functional Keywords: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O95271
• Total number of polymer chains: 2
• Total formula weight: 52523.58

Authors

Stams, T.,Kirby, C. (deposition date: 2011-11-03, release date: 2012-02-15, Last modification date: 2024-02-28)

• Primary citation: Kirby, C.A.,Cheung, A.,Fazal, A.,Shultz, M.D.,Stams, T.; Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.; Acta Crystallogr.,Sect.F, 68:115-118, 2012; PubMed: 22297980; DOI: 10.1107/S1744309111051219

Experimental method

X-RAY DIFFRACTION (2 Å)