3UH4
TANKYRASE-1 complexed with NVP-XAV939
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tankyrase-1 | polymer | 224 | 25409.7 | 2 | UniProt (O95271) Pfam (PF00644) | Homo sapiens (human) | TANK1, Poly [ADP-ribose] polymerase 5A, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I |
| 2 | C, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, K (A, B) | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol | non-polymer | 312.3 | 2 | Chemie (XAV) | |||
| 4 | E, F, G, H, L... (A, B) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 5 | I, O, P (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | Q, R (A, B) | water | water | 18.0 | 316 | Chemie (HOH) |
Sequence modifications
A, B: 1105 - 1327 (UniProt: O95271)
| PDB | External Database | Details |
|---|---|---|
| Gly 1104 | - | expression tag |
| Ile 1266 | Met 1266 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50819.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1704.2 | |
| All* | Total formula weight | 52523.6 |
