3UA8
Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2
Summary for 3UA8
Entry DOI | 10.2210/pdb3ua8/pdb |
Related | 3R7X |
Descriptor | Glutamate receptor 2, N-methyl-1-{3-[(methylsulfonyl)amino]-2,4-dioxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-6-yl}-1H-imidazole-4-carboxamide (3 entities in total) |
Functional Keywords | ion channel, ionic channel, postsynaptic membrane, transmembrane, transport protein-antagonist complex, transport protein/antagonist |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P42262 |
Total number of polymer chains | 1 |
Total formula weight | 29794.23 |
Authors | Kallen, J. (deposition date: 2011-10-21, release date: 2012-01-11, Last modification date: 2023-09-13) |
Primary citation | Orain, D.,Ofner, S.,Koller, M.,Carcache, D.A.,Froestl, W.,Allgeier, H.,Rasetti, V.,Nozulak, J.,Mattes, H.,Soldermann, N.,Floersheim, P.,Desrayaud, S.,Kallen, J.,Lingenhoehl, K.,Urwyler, S. 6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists. Bioorg.Med.Chem.Lett., 22:996-999, 2012 Cited by PubMed: 22197388DOI: 10.1016/j.bmcl.2011.12.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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