3U88
Crystal structure of human menin in complex with MLL1 and LEDGF
Summary for 3U88
Entry DOI | 10.2210/pdb3u88/pdb |
Related | 3U84 3U85 3U86 |
Descriptor | Menin, Histone-lysine N-methyltransferase 2A, Lens epithelium-derived growth factor, ... (8 entities in total) |
Functional Keywords | menin, men1, mll, jund, ledgf, tpr, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : O00255 O75475 Nucleus . MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164 |
Total number of polymer chains | 6 |
Total formula weight | 161943.68 |
Authors | |
Primary citation | Huang, J.,Gurung, B.,Wan, B.,Matkar, S.,Veniaminova, N.A.,Wan, K.,Merchant, J.L.,Hua, X.,Lei, M. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482:542-546, 2012 Cited by PubMed: 22327296DOI: 10.1038/nature10806 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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