3U88
Crystal structure of human menin in complex with MLL1 and LEDGF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Menin | polymer | 550 | 61061.2 | 2 | UniProt (O00255) Pfam (PF05053) | Homo sapiens (Human) | |
| 2 | C, E (M, N) | Histone-lysine N-methyltransferase 2A | polymer | 75 | 7782.7 | 2 | UniProt (Q03164) | Homo sapiens (Human) | Lysine N-methyltransferase 2A,ALL-1,CXXC-type zinc finger protein 7,Myeloid/lymphoid or mixed-lineage leukemia,Myeloid/lymphoid or mixed-lineage leukemia protein 1,Trithorax-like protein,Zinc finger protein HRX |
| 3 | D, F (C, D) | Lens epithelium-derived growth factor | polymer | 89 | 10346.1 | 2 | UniProt (O75475) Pfam (PF11467) | Homo sapiens (Human) | CLL-associated antigen KW-7,Dense fine speckles 70 kDa protein,DFS 70,Transcriptional coactivator p75/p52 |
| 4 | G, P (A, B) | CHOLIC ACID | non-polymer | 408.6 | 2 | Chemie (CHD) PubChem (16401672) PubChem (16758100) PubChem (18528842) PubChem (20638765) PubChem (23636694) PubChem (23640631) PubChem (23876184) PubChem (24836753) PubChem (24883735) PubChem (16401251) PubChem (21139644) PubChem (1762378) PubChem (44339334) PubChem (46780112) PubChem (43835083) PubChem (44135469) PubChem (59130005) PubChem (59381614) PubChem (44629918) PubChem (44657327) PubChem (59903914) PubChem (67122255) PubChem (45114537) PubChem (45382168) PubChem (69904012) PubChem (46397523) PubChem (46783697) PubChem (130213) PubChem (145883) PubChem (70866085) PubChem (71001249) PubChem (239672) PubChem (71314856) PubChem (71752895) PubChem (74765127) PubChem (49791911) PubChem (49796810) PubChem (89830646) PubChem (91128541) PubChem (5283876) PubChem (5283879) PubChem (5283880) PubChem (5283872) PubChem (5283874) PubChem (98044963) PubChem (50989873) PubChem (51432410) PubChem (51546373) PubChem (99565617) PubChem (122645815) PubChem (124161889) PubChem (53298695) PubChem (53393606) PubChem (53477699) PubChem (124318072) PubChem (124488681) PubChem (125037036) PubChem (126577457) PubChem (129274856) PubChem (129274855) PubChem (129359810) PubChem (133135020) PubChem (133126746) PubChem (11350342) PubChem (12303168) PubChem (13020196) PubChem (57937243) PubChem (162771689) PubChem (163059393) PubChem (163059399) PubChem (163059389) PubChem (58133002) PubChem (58582306) PubChem (58984417) PubChem (59032051) PubChem (166858402) PubChem (59316662) PubChem (59877711) PubChem (59963674) PubChem (59997751) PubChem (60076012) PubChem (60098994) PubChem (60114995) PubChem (66678354) PubChem (68097396) PubChem (68131418) PubChem (68318251) PubChem (68338620) PubChem (68372213) PubChem (71260265) PubChem (70649328) PubChem (70824975) PubChem (70930320) PubChem (70930789) PubChem (70960845) PubChem (91810856) PubChem (99564899) PubChem (99565857) PubChem (117684834) PubChem (117767695) PubChem (117944573) PubChem (118241311) PubChem (121232934) PubChem (303) PubChem (122537896) PubChem (122537897) PubChem (6676) PubChem (122644681) PubChem (122644923) PubChem (122646384) PubChem (122340) PubChem (160636) PubChem (221493) PubChem (376829) PubChem (124328806) PubChem (124364505) PubChem (124425250) PubChem (124488680) PubChem (124511215) PubChem (124518077) PubChem (124518078) PubChem (124518446) PubChem (439520) PubChem (440427) PubChem (124761950) PubChem (637625) PubChem (124841930) PubChem (124896923) PubChem (124896924) PubChem (124896925) PubChem (124896926) PubChem (124904187) PubChem (124904188) PubChem (124906682) PubChem (124906683) PubChem (124914603) PubChem (124914604) PubChem (124914605) PubChem (124914606) PubChem (3246132) PubChem (5283869) PubChem (5283870) PubChem (5283871) PubChem (5283873) PubChem (5283875) PubChem (5283877) PubChem (5283878) PubChem (5302608) PubChem (5315844) PubChem (125027431) PubChem (125037037) PubChem (6708709) PubChem (6850901) PubChem (6850905) PubChem (126422551) PubChem (126422552) PubChem (126577461) PubChem (126672319) PubChem (126969154) PubChem (9802771) PubChem (9846429) PubChem (9866174) PubChem (71172094) PubChem (129106816) PubChem (129460958) PubChem (129600748) PubChem (129628082) PubChem (130220803) PubChem (12080557) PubChem (12303167) PubChem (12303172) PubChem (12303175) PubChem (12303178) PubChem (12303180) PubChem (13020205) PubChem (131700165) PubChem (132441695) PubChem (133548348) PubChem (133612061) PubChem (133655733) PubChem (133687870) PubChem (133688934) PubChem (134462403) PubChem (134555902) PubChem (134866321) PubChem (135373095) PubChem (137474142) PubChem (138107312) PubChem (139248576) PubChem (139291795) PubChem (139372812) PubChem (140618124) PubChem (141854542) PubChem (142134118) PubChem (143658950) PubChem (144316980) PubChem (145264188) PubChem (145714625) PubChem (146030145) PubChem (146665897) PubChem (154033190) PubChem (154036252) PubChem (154747009) PubChem (154825357) PubChem (155275443) PubChem (155605940) PubChem (157048615) PubChem (157269375) PubChem (157351909) PubChem (157383333) PubChem (158041002) PubChem (158420924) PubChem (158675416) PubChem (160081178) PubChem (160743345) PubChem (160917187) PubChem (161973449) PubChem (163059390) PubChem (163059391) PubChem (163059392) PubChem (163059394) PubChem (163059395) PubChem (163059396) PubChem (163059397) PubChem (163059398) PubChem (163059400) PubChem (163452349) PubChem (163452350) PubChem (163452351) PubChem (167344826) PubChem (168841979) PubChem (168841990) PubChem (168845540) PubChem (169410142) PubChem (169436432) PubChem (171721516) PubChem (157060709) | |||
| 5 | H, J, R, X, Y (A, B, C) | L-CANAVANINE | non-polymer | 176.2 | 5 | Chemie (GGB) | |||
| 6 | I, Q (A, B) | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol | non-polymer | 326.4 | 2 | Chemie (0BR) PubChem (16401293) PubChem (16667668) PubChem (18397927) PubChem (22297909) PubChem (22831447) PubChem (22831452) PubChem (23305116) PubChem (21862293) PubChem (2734756) PubChem (44483268) PubChem (44511035) PubChem (44593813) PubChem (66589237) PubChem (45479755) PubChem (89002) PubChem (76974754) PubChem (1257698) PubChem (5318127) PubChem (6604591) PubChem (6921587) PubChem (6950350) PubChem (54669737) PubChem (13550109) PubChem (57992270) PubChem (169791445) PubChem (70946321) PubChem (73951178) PubChem (122163733) PubChem (3649) PubChem (10651) PubChem (91503) PubChem (121515) PubChem (442912) PubChem (638267) PubChem (688077) PubChem (5318125) PubChem (6432105) PubChem (6432519) PubChem (6604612) PubChem (6916032) PubChem (6916040) PubChem (7069816) PubChem (11645562) PubChem (11667010) PubChem (11859599) PubChem (12166995) PubChem (13550110) PubChem (13550111) PubChem (132965784) PubChem (134859574) PubChem (138107851) PubChem (138319400) PubChem (140543818) PubChem (155372243) PubChem (155372245) PubChem (169777677) PubChem (172431652) PubChem (174432729) | |||
| 7 | CA, K, L, M, S... (D, A, B, C) | GLYOXYLIC ACID | non-polymer | 74.0 | 6 | Chemie (GLV) PubChem (760) | |||
| 8 | AA, BA, N, O, T... (N, A, B, M) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) |
Sequence modifications
A, B: 2 - 459 (UniProt: O00255)
A, B: 520 - 610 (UniProt: O00255)
M, N: 36 - 153 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
M, N: 36 - 153 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ser 5 | - | expression tag |
| Arg 6 | - | expression tag |
| Trp 7 | - | expression tag |
| Arg 8 | - | expression tag |
| Phe 9 | - | expression tag |
| Pro 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Arg 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Gly 14 | - | expression tag |
| Thr 15 | - | expression tag |
| Gly 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Arg 25 | - | expression tag |
| Gly 26 | - | expression tag |
| Leu 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Gly 29 | - | expression tag |
| Ala 30 | - | expression tag |
| Pro 31 | - | expression tag |
| Arg 32 | - | expression tag |
| Gln 33 | - | expression tag |
| Arg 34 | - | expression tag |
| Val 35 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 158380.1 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 3563.6 | |
| All* | Total formula weight | 161943.7 |
