3TZ7
Kinase domain of cSrc in complex with RL103
Summary for 3TZ7
Entry DOI | 10.2210/pdb3tz7/pdb |
Related | 3F3V 3F3W 3TZ8 3TZ9 |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, N-(4-{[4-({[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}quinazolin-6-yl)-4-(dimethylamino)butanamide (2 entities in total) |
Functional Keywords | type ii, allosteric, dfg-out, drug resistance mutations, tyrosin-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Gallus gallus (Chicken) |
Cellular location | Cell membrane (By similarity): P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66726.92 |
Authors | Gruetter, C.,Richters, A.,Rauh, D. (deposition date: 2011-09-27, release date: 2012-10-10, Last modification date: 2023-11-01) |
Primary citation | Richters, A.,Getlik, M.,Gruetter, C.,Schneider, R.,Heuckmann, J.M.,Heynck, S.,Sos, M.L.,Thomas, R.K.,Rauh, D. Overcoming Gatekeeper Mutations in cSrc and Abl by Hybrid Compound Design To be Published, |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
Download full validation report