3TV8

Pharmacological Chaperoning in Human alpha-Galactosidase

3TV8 の概要

• エントリーDOI: 10.2210/pdb3tv8/pdb
• 関連するPDBエントリー: 1R46 1R47 3HG2 3HG3 3S5Y 3S5Z
• 分子名称: Alpha-galactosidase A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: pharmacological chaperone, (beta/alpha)8 barrel, carbohydrate-binding protein, glycosidase, glycoprotein, n-linked glycosylation, lysosome, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96436.87

構造登録者

Rogich, J.J.,Guce, A.I.,Clark, N.E.,Garman, S.C. (登録日: 2011-09-19, 公開日: 2012-01-04, 最終更新日: 2023-09-13)

• 主引用文献: Guce, A.I.,Clark, N.E.,Rogich, J.J.,Garman, S.C.; The molecular basis of pharmacological chaperoning in human alpha-galactosidase; Chem.Biol., 18:1521-1526, 2011; PubMed: 22195554; DOI: 10.1016/j.chembiol.2011.10.012

実験手法

X-RAY DIFFRACTION (2.639 Å)