3TNH

CDK9/cyclin T in complex with CAN508

Summary for 3TNH

• Entry DOI: 10.2210/pdb3tnh/pdb
• Related: 3TNI 3TNW
• Descriptor: Cyclin-dependent kinase 9, Cyclin-T1, 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL (3 entities in total)
• Functional Keywords: kinase, cyclin, phosphtransfer, cyclin t, phosphorylated on threonine 186, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P50750 O60563
• Total number of polymer chains: 2
• Total formula weight: 68411.75

Authors

Baumli, S.,Hole, A.J.,Endicott, J.A. (deposition date: 2011-09-01, release date: 2012-02-15, Last modification date: 2023-09-13)

• Primary citation: Baumli, S.,Hole, A.J.,Noble, M.E.,Endicott, J.A.; The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.; Acs Chem.Biol., 7:811-816, 2012; PubMed: 22292676; DOI: 10.1021/cb2004516

Experimental method

X-RAY DIFFRACTION (3.202 Å)