3TNH
CDK9/cyclin T in complex with CAN508
Summary for 3TNH
Entry DOI | 10.2210/pdb3tnh/pdb |
Related | 3TNI 3TNW |
Descriptor | Cyclin-dependent kinase 9, Cyclin-T1, 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL (3 entities in total) |
Functional Keywords | kinase, cyclin, phosphtransfer, cyclin t, phosphorylated on threonine 186, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P50750 O60563 |
Total number of polymer chains | 2 |
Total formula weight | 68411.75 |
Authors | Baumli, S.,Hole, A.J.,Endicott, J.A. (deposition date: 2011-09-01, release date: 2012-02-15, Last modification date: 2023-09-13) |
Primary citation | Baumli, S.,Hole, A.J.,Noble, M.E.,Endicott, J.A. The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7:811-816, 2012 Cited by PubMed: 22292676DOI: 10.1021/cb2004516 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.202 Å) |
Structure validation
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