3TMZ

Crystal Structure of P450 2B4(H226Y) in complex with Amlodipine

3TMZ の概要

• エントリーDOI: 10.2210/pdb3tmz/pdb
• 関連するPDBエントリー: 1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 3KW4 3ME6 3MVR 3R1A 3R1B
• 分子名称: Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (5 entities in total)
• 機能のキーワード: p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56097.89

構造登録者

Shah, M.B.,Pascual, J.,Stout, C.D.,Halpert, J.R. (登録日: 2011-09-01, 公開日: 2012-09-12, 最終更新日: 2023-09-13)

• 主引用文献: Shah, M.B.,Wilderman, P.R.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R.; Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules.; Biochemistry, 51:7225-7238, 2012; PubMed: 22909231; DOI: 10.1021/bi300894z

実験手法

X-RAY DIFFRACTION (2.248 Å)