3TGX

IL-21:IL21R complex

Summary for 3TGX

• Entry DOI: 10.2210/pdb3tgx/pdb
• Descriptor: Interleukin-21 receptor, Interleukin-21, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: class i cytokine, class i cytokine receptor, sugarbridge, fibronectin domain, signaling, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 343282.41

Authors

Hamming, O.J.,Kang, L.,Svenson, A.,Karlsen, J.L.,Rahbek-Nielsen, H.,Paludan, S.R.,Hjort, S.A.,Bondensgaard, K.,Hartmann, R. (deposition date: 2011-08-18, release date: 2012-02-15, Last modification date: 2023-12-27)

• Primary citation: Hamming, O.J.,Kang, L.,Svensson, A.,Karlsen, J.L.,Rahbek-Nielsen, H.,Paludan, S.R.,Hjorth, S.A.,Bondensgaard, K.,Hartmann, R.; The crystal structure of the interleukin 21 receptor bound to interleukin 21 reveals that a sugar chain interacting with the WSXWS motif is an integral part of the interleukin 21 receptor.; J.Biol.Chem., 2012; PubMed: 22235133; DOI: 10.1074/jbc.M111.311084

Experimental method

X-RAY DIFFRACTION (2.8 Å)