3TGX

IL-21:IL21R complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004896	molecular_function	cytokine receptor activity
A	0016020	cellular_component	membrane
B	0001819	biological_process	positive regulation of cytokine production
B	0002314	biological_process	germinal center B cell differentiation
B	0002639	biological_process	positive regulation of immunoglobulin production
B	0005125	molecular_function	cytokine activity
B	0005126	molecular_function	cytokine receptor binding
B	0005134	molecular_function	interleukin-2 receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006952	biological_process	defense response
B	0006955	biological_process	immune response
B	0007165	biological_process	signal transduction
B	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
B	0007260	biological_process	tyrosine phosphorylation of STAT protein
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009615	biological_process	response to virus
B	0016064	biological_process	immunoglobulin mediated immune response
B	0030101	biological_process	natural killer cell activation
B	0030890	biological_process	positive regulation of B cell proliferation
B	0032729	biological_process	positive regulation of type II interferon production
B	0032740	biological_process	positive regulation of interleukin-17 production
B	0034105	biological_process	positive regulation of tissue remodeling
B	0042102	biological_process	positive regulation of T cell proliferation
B	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
B	0045954	biological_process	positive regulation of natural killer cell mediated cytotoxicity
B	0048468	biological_process	cell development
B	0048469	biological_process	cell maturation
B	0050729	biological_process	positive regulation of inflammatory response
B	0051251	biological_process	positive regulation of lymphocyte activation
B	0051607	biological_process	defense response to virus
B	0061470	biological_process	T follicular helper cell differentiation
B	0098586	biological_process	cellular response to virus
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
D	0001819	biological_process	positive regulation of cytokine production
D	0002314	biological_process	germinal center B cell differentiation
D	0002639	biological_process	positive regulation of immunoglobulin production
D	0005125	molecular_function	cytokine activity
D	0005126	molecular_function	cytokine receptor binding
D	0005134	molecular_function	interleukin-2 receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005886	cellular_component	plasma membrane
D	0006952	biological_process	defense response
D	0006955	biological_process	immune response
D	0007165	biological_process	signal transduction
D	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
D	0007260	biological_process	tyrosine phosphorylation of STAT protein
D	0008284	biological_process	positive regulation of cell population proliferation
D	0009615	biological_process	response to virus
D	0016064	biological_process	immunoglobulin mediated immune response
D	0030101	biological_process	natural killer cell activation
D	0030890	biological_process	positive regulation of B cell proliferation
D	0032729	biological_process	positive regulation of type II interferon production
D	0032740	biological_process	positive regulation of interleukin-17 production
D	0034105	biological_process	positive regulation of tissue remodeling
D	0042102	biological_process	positive regulation of T cell proliferation
D	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
D	0045954	biological_process	positive regulation of natural killer cell mediated cytotoxicity
D	0048468	biological_process	cell development
D	0048469	biological_process	cell maturation
D	0050729	biological_process	positive regulation of inflammatory response
D	0051251	biological_process	positive regulation of lymphocyte activation
D	0051607	biological_process	defense response to virus
D	0061470	biological_process	T follicular helper cell differentiation
D	0098586	biological_process	cellular response to virus
E	0004896	molecular_function	cytokine receptor activity
E	0016020	cellular_component	membrane
F	0001819	biological_process	positive regulation of cytokine production
F	0002314	biological_process	germinal center B cell differentiation
F	0002639	biological_process	positive regulation of immunoglobulin production
F	0005125	molecular_function	cytokine activity
F	0005126	molecular_function	cytokine receptor binding
F	0005134	molecular_function	interleukin-2 receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005886	cellular_component	plasma membrane
F	0006952	biological_process	defense response
F	0006955	biological_process	immune response
F	0007165	biological_process	signal transduction
F	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
F	0007260	biological_process	tyrosine phosphorylation of STAT protein
F	0008284	biological_process	positive regulation of cell population proliferation
F	0009615	biological_process	response to virus
F	0016064	biological_process	immunoglobulin mediated immune response
F	0030101	biological_process	natural killer cell activation
F	0030890	biological_process	positive regulation of B cell proliferation
F	0032729	biological_process	positive regulation of type II interferon production
F	0032740	biological_process	positive regulation of interleukin-17 production
F	0034105	biological_process	positive regulation of tissue remodeling
F	0042102	biological_process	positive regulation of T cell proliferation
F	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
F	0045954	biological_process	positive regulation of natural killer cell mediated cytotoxicity
F	0048468	biological_process	cell development
F	0048469	biological_process	cell maturation
F	0050729	biological_process	positive regulation of inflammatory response
F	0051251	biological_process	positive regulation of lymphocyte activation
F	0051607	biological_process	defense response to virus
F	0061470	biological_process	T follicular helper cell differentiation
F	0098586	biological_process	cellular response to virus
G	0004896	molecular_function	cytokine receptor activity
G	0016020	cellular_component	membrane
H	0001819	biological_process	positive regulation of cytokine production
H	0002314	biological_process	germinal center B cell differentiation
H	0002639	biological_process	positive regulation of immunoglobulin production
H	0005125	molecular_function	cytokine activity
H	0005126	molecular_function	cytokine receptor binding
H	0005134	molecular_function	interleukin-2 receptor binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005886	cellular_component	plasma membrane
H	0006952	biological_process	defense response
H	0006955	biological_process	immune response
H	0007165	biological_process	signal transduction
H	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
H	0007260	biological_process	tyrosine phosphorylation of STAT protein
H	0008284	biological_process	positive regulation of cell population proliferation
H	0009615	biological_process	response to virus
H	0016064	biological_process	immunoglobulin mediated immune response
H	0030101	biological_process	natural killer cell activation
H	0030890	biological_process	positive regulation of B cell proliferation
H	0032729	biological_process	positive regulation of type II interferon production
H	0032740	biological_process	positive regulation of interleukin-17 production
H	0034105	biological_process	positive regulation of tissue remodeling
H	0042102	biological_process	positive regulation of T cell proliferation
H	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
H	0045954	biological_process	positive regulation of natural killer cell mediated cytotoxicity
H	0048468	biological_process	cell development
H	0048469	biological_process	cell maturation
H	0050729	biological_process	positive regulation of inflammatory response
H	0051251	biological_process	positive regulation of lymphocyte activation
H	0051607	biological_process	defense response to virus
H	0061470	biological_process	T follicular helper cell differentiation
H	0098586	biological_process	cellular response to virus
I	0004896	molecular_function	cytokine receptor activity
I	0016020	cellular_component	membrane
J	0001819	biological_process	positive regulation of cytokine production
J	0002314	biological_process	germinal center B cell differentiation
J	0002639	biological_process	positive regulation of immunoglobulin production
J	0005125	molecular_function	cytokine activity
J	0005126	molecular_function	cytokine receptor binding
J	0005134	molecular_function	interleukin-2 receptor binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005886	cellular_component	plasma membrane
J	0006952	biological_process	defense response
J	0006955	biological_process	immune response
J	0007165	biological_process	signal transduction
J	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
J	0007260	biological_process	tyrosine phosphorylation of STAT protein
J	0008284	biological_process	positive regulation of cell population proliferation
J	0009615	biological_process	response to virus
J	0016064	biological_process	immunoglobulin mediated immune response
J	0030101	biological_process	natural killer cell activation
J	0030890	biological_process	positive regulation of B cell proliferation
J	0032729	biological_process	positive regulation of type II interferon production
J	0032740	biological_process	positive regulation of interleukin-17 production
J	0034105	biological_process	positive regulation of tissue remodeling
J	0042102	biological_process	positive regulation of T cell proliferation
J	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
J	0045954	biological_process	positive regulation of natural killer cell mediated cytotoxicity
J	0048468	biological_process	cell development
J	0048469	biological_process	cell maturation
J	0050729	biological_process	positive regulation of inflammatory response
J	0051251	biological_process	positive regulation of lymphocyte activation
J	0051607	biological_process	defense response to virus
J	0061470	biological_process	T follicular helper cell differentiation
J	0098586	biological_process	cellular response to virus
K	0004896	molecular_function	cytokine receptor activity
K	0016020	cellular_component	membrane
L	0001819	biological_process	positive regulation of cytokine production
L	0002314	biological_process	germinal center B cell differentiation
L	0002639	biological_process	positive regulation of immunoglobulin production
L	0005125	molecular_function	cytokine activity
L	0005126	molecular_function	cytokine receptor binding
L	0005134	molecular_function	interleukin-2 receptor binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006952	biological_process	defense response
L	0006955	biological_process	immune response
L	0007165	biological_process	signal transduction
L	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
L	0007260	biological_process	tyrosine phosphorylation of STAT protein
L	0008284	biological_process	positive regulation of cell population proliferation
L	0009615	biological_process	response to virus
L	0016064	biological_process	immunoglobulin mediated immune response
L	0030101	biological_process	natural killer cell activation
L	0030890	biological_process	positive regulation of B cell proliferation
L	0032729	biological_process	positive regulation of type II interferon production
L	0032740	biological_process	positive regulation of interleukin-17 production
L	0034105	biological_process	positive regulation of tissue remodeling
L	0042102	biological_process	positive regulation of T cell proliferation
L	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
L	0045954	biological_process	positive regulation of natural killer cell mediated cytotoxicity
L	0048468	biological_process	cell development
L	0048469	biological_process	cell maturation
L	0050729	biological_process	positive regulation of inflammatory response
L	0051251	biological_process	positive regulation of lymphocyte activation
L	0051607	biological_process	defense response to virus
L	0061470	biological_process	T follicular helper cell differentiation
L	0098586	biological_process	cellular response to virus
M	0004896	molecular_function	cytokine receptor activity
M	0016020	cellular_component	membrane
N	0001819	biological_process	positive regulation of cytokine production
N	0002314	biological_process	germinal center B cell differentiation
N	0002639	biological_process	positive regulation of immunoglobulin production
N	0005125	molecular_function	cytokine activity
N	0005126	molecular_function	cytokine receptor binding
N	0005134	molecular_function	interleukin-2 receptor binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005886	cellular_component	plasma membrane
N	0006952	biological_process	defense response
N	0006955	biological_process	immune response
N	0007165	biological_process	signal transduction
N	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
N	0007260	biological_process	tyrosine phosphorylation of STAT protein
N	0008284	biological_process	positive regulation of cell population proliferation
N	0009615	biological_process	response to virus
N	0016064	biological_process	immunoglobulin mediated immune response
N	0030101	biological_process	natural killer cell activation
N	0030890	biological_process	positive regulation of B cell proliferation
N	0032729	biological_process	positive regulation of type II interferon production
N	0032740	biological_process	positive regulation of interleukin-17 production
N	0034105	biological_process	positive regulation of tissue remodeling
N	0042102	biological_process	positive regulation of T cell proliferation
N	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
N	0045954	biological_process	positive regulation of natural killer cell mediated cytotoxicity
N	0048468	biological_process	cell development
N	0048469	biological_process	cell maturation
N	0050729	biological_process	positive regulation of inflammatory response
N	0051251	biological_process	positive regulation of lymphocyte activation
N	0051607	biological_process	defense response to virus
N	0061470	biological_process	T follicular helper cell differentiation
N	0098586	biological_process	cellular response to virus
O	0004896	molecular_function	cytokine receptor activity
O	0016020	cellular_component	membrane
P	0001819	biological_process	positive regulation of cytokine production
P	0002314	biological_process	germinal center B cell differentiation
P	0002639	biological_process	positive regulation of immunoglobulin production
P	0005125	molecular_function	cytokine activity
P	0005126	molecular_function	cytokine receptor binding
P	0005134	molecular_function	interleukin-2 receptor binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005886	cellular_component	plasma membrane
P	0006952	biological_process	defense response
P	0006955	biological_process	immune response
P	0007165	biological_process	signal transduction
P	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
P	0007260	biological_process	tyrosine phosphorylation of STAT protein
P	0008284	biological_process	positive regulation of cell population proliferation
P	0009615	biological_process	response to virus
P	0016064	biological_process	immunoglobulin mediated immune response
P	0030101	biological_process	natural killer cell activation
P	0030890	biological_process	positive regulation of B cell proliferation
P	0032729	biological_process	positive regulation of type II interferon production
P	0032740	biological_process	positive regulation of interleukin-17 production
P	0034105	biological_process	positive regulation of tissue remodeling
P	0042102	biological_process	positive regulation of T cell proliferation
P	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
P	0045954	biological_process	positive regulation of natural killer cell mediated cytotoxicity
P	0048468	biological_process	cell development
P	0048469	biological_process	cell maturation
P	0050729	biological_process	positive regulation of inflammatory response
P	0051251	biological_process	positive regulation of lymphocyte activation
P	0051607	biological_process	defense response to virus
P	0061470	biological_process	T follicular helper cell differentiation
P	0098586	biological_process	cellular response to virus

Functional Information from PROSITE/UniProt

site_id	PS01355
Number of Residues	34
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. FrkdssyelqVRagpmpgssyqgt........WSeWSdpviF

Chain	Residue	Details
A	PHE171-PHE204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	776
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22235133","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Glycosylation: {"description":"C-linked (Man) tryptophan","evidences":[{"source":"PubMed","id":"22235133","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	436
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---